No, you waited long enough between consuming alcohol and taking acetaminophen. The reason why you shouldn’t take them together is that they sort of amplify each other’s harmful effects on the liver, but after sixteen hours the alcohol would be well ahead of acetaminophen in your system. So if I have a cold, I can choose to not sleep (not a good thing for the cold or me), take sometihing less effective or with unpleasant side effects, or take the risk of the Tylenol. I try to leave a WIDE margin of safety, like only taking a qarter of the maximum dose in a 24 hour period, so hopefully that's enough. This question has a double-barreled answer. Yes, you can take acetaminophen (aka Tylenol, which is a brand-name, which we avoid using in practice, because often several brand names are available for the same drug.) MONDAY, Nov. 4 (HealthDay News) -- Combining acetaminophen pain relievers, which include Tylenol, and even light amounts of alcohol can more than double the risk of kidney disease, new research. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Krauser on can you take advil after drinking: Taking aleve (naproxen) immediately after alcohol consumption significant increases the risk of GI damage from this med. I've looked into it on the net but never really got time estimates for after drinking for when I could take any pills, but oh well I suppose I'll just tuff it out for the night thanks though :). Edit: I hate pills but just as equally I dislike this certain pain I have going on in my shoulder before surgery. If you wake up with a headache after a night of overindulging, sometimes figuring out what painkiller to take can make the headache even worse. Taking acetaminophen (aka Tylenol) can lead to liver. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Grin on how many hours after taking tylenol can you drink: Alcohol. A chronic heavy drinker (3 or more drinks per day) should not take tylenol (acetaminophen) at all. If you are an occasional drinker, do not both in less than 24 hours of each other. Women are more. As long as you take acetaminophen as directed, you can drink alcohol in moderation. Drinking in moderation means having no more than three drinks per day.